Sickle cell trait: not as benign as once thought
نویسندگان
چکیده
We describe a case of renal papillary necrosis in a middle-aged female with sickle cell trait who presented with gross hematuria. We wish to highlight this case for several reasons. Sickle cell trait is often viewed as a benign condition despite the fact that it is associated with significant morbidity such as renal papillary necrosis and renal medullary carcinoma. Appropriate evaluation needs to be undertaken to promptly diagnose renal papillary necrosis and differentiate it from renal medullary carcinoma as this can result in deadly consequences for patients. CT urography has emerged as a diagnostic study to evaluate hematuria in such patients. We review the pathophysiology, diagnosis, and management of renal papillary necrosis in patients with sickle cell trait.
منابع مشابه
Pre-marriage Sickle Cell Screening Program in South Region of Iran, A Pilot Study on 50 Cases of Sickle Trait
Background: Studies have demonstrated that sickle cell trait can be found in an asymptomatic healthy carrier with normal complete blood count (CBC) and red blood cell (RBC) indices. According to Iranian Ministry of Health bulletin instructions, prenuptial Thalassemia Screening Program (TSP) primarily depends on RBC indices which are measured through a routine CBC. Only when these levels are bel...
متن کاملPoint:Counterpoint: Sickle cell trait should/should not be considered asymptomatic and as a benign condition during physical activity POINT: SICKLE CELL TRAIT SHOULD BE CONSIDERED ASYMPTOMATIC AND AS A BENIGN CONDITION DURING PHYSICAL ACTIVITY
Sickle cell trait (SCT) is found in 8% of African Americans and may be found in up to 40% of West Africans. However, most of them are unaware of their status. This observation suggests that SCT may be asymptomatic and remains a benign condition for daily life activities (5). Indeed, numerous studies have reported that subjects with SCT had normal growth and development, normal morbidity (10) an...
متن کاملFemoral Head Avascular Necrosis in Heterozygous Sickle Haemoglobin, the Role of Parenteral Drug Abuse: A Case Report
Sickle cell trait is a benign haemoglobin disorder which rarely results in disease or complications. A few cases of osteonecrosis have been reported in the literature in parts of the world with advanced health care system. There are various predispositions to developing avascular necrosis in general, while the sickle beta globin gene inheritance is the most efficient factor. Injection drug abus...
متن کاملSickle Cell Trait Causing Splanchnic Venous Thrombosis
Sickle cell trait is considered as a benign condition as these individuals carry only one defective gene and typically have their life span similar to the normal population without any health problems related to sickle cell. Only under extreme conditions, red cells become sickled and can cause clinical complications including hematuria and splenic infarction. Although twofold increased risk of ...
متن کاملSickle Cell Trait: A Benign State?
BACKGROUND Sickle cell trait (SCT) is the heterozygous form of sickle cell disease and expectedly should be a benign state with no complications ascribed to it. There are numerous reports challenging its being a benign condition, though this is controversial. METHODS AND RESULTS A review of the results of the accompanying investigations done on some of the patients show that beta thalassemia ...
متن کامل